DOI: 10.14704/nq.2018.16.6.1630

Mutation of Brain Function in Patients with Herpes Zoster Pain

Jun Xie, Gang Liu, Siyu Wang, Lei Yan, Bei Zhao


This paper aims to observe the basal brain region activity in patients with postherpetic neuralgia using functional magnetic resonance imaging (FMRI) and amplitude of low frequency fluctuation (ALFF). The best way is practice the FMRI scans on patients with postherpetic neuralgia and sex- and age-matched healthy people. Under the control of impacts from age, sex and average education years, we make an associated analysis on the threshold of herpes zoster pain of every voxel against the clinical course and visual analogue scale of every subject using multiple regression. The findings show that, as compared to the healthy volunteers, patients have some brain regions where scale relevant values increase such as posterior lobe of right cerebellum, dorsolateral prefrontal lobe, right parietal lobe, and right gyrus lingualis. It is concluded that the cerebral regions that involve in the emotional alertness behavior and attention play an important role in the occurrence and maintenance of chronic pain of postherpetic neuralgia. Spinal dorsal horn neurons continuously transmit pain signals into the central nervous system, which can lead to mutation in the basal brain activities of patients.


Herpes Zoster, Brain Activity, Functional Changes

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