DOI: 10.14704/nq.2018.16.6.1632

Relationship between Moderate-Severe Periodontitis and Ischemic Stroke

Yu Gao, Zhifeng Wang, Xu Qiao, Xin Xu


This paper aims to make a preliminary discussion on the relationship between periodontitis, serum inflammatory factors and ischemic stroke based on measurements of the first two diseases. A case-control study operates between patients with ischemic stroke (experimental group) and healthy cases (control group) in comparison to the incidence of periodontitis, serum hype-sensitivity C-reactive protein, interleukin and tumor necrosis factor. The results reveal that the experimental group presents higher than the control group in all these areas, and the differences in these regards are statistically significant. In the end, it is concluded that periodontitis and serum inflammatory factors are correlated to ischemic stroke. Hype-sensitivity C-reactive protein, interleukin and tumor necrosis factor may serve as the serological indicators for testing the periodontitis and ischemic stroke in clinical practices.


Periodontitis, Ischemic Stroke, Relationship

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Fichtlscherer S, Rosenberger G, Walter DH, Breuer S, Dimmeler S. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 2000; 102(9): 1-6.

Loos BG, Craandijk J, Hoek FJ, Velden UVD. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. Journal of Periodontology 2000; 71(10): 1528-34.

Pickett CA, Jackson JL, Hemann B. A. Carotid bruits and cerebrovascular disease risk: A meta-analysis. Journal of Vascular Surgery 2010; 53(4): 2295-2302.

Sawecka J, Kornacka L, Malec J. Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology 2003; 95(5): 559-69.

Slade MS, Simmons RL, Yunis E, Greenberg LJ. Immunodepression after major surgery in normal patients. Surgery 1975; 78(3): 363-72.

Wilmore DW. Catabolic illness–stratgies for enhancing recovery. New England Journal of Medicine 1991; 325(10): 695- 702.

Yamazaki K, Honda T, Oda T, Ueki-Maruyama K, Nakajima T. Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients. Journal of Periodontal Research 2005; 40(1): 53-58.

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