DOI: 10.14704/nq.2018.16.6.1655

Clinical Study on Prognostic Factors and Nursing of Breast Cancer with Brain Metastases

Ying Zhou, Kefang Zhong, Fang Zhou


This paper aims to explore the clinical features and prognostic factors of breast cancer patients with brain metastases. To this end, the influencing factors such as clinical pathological data and therapeutic measures etc. on the prognosis of patients with BCBM treated in hospitals were retrospectively analyzed, and the proportional hazard model was established to make multivariate analysis. The results show that the disease-free survival time, whether with visceral metastasis, KPS score, whether with meningeal metastasis, brain metastasis number are significantly correlated to the survival time of patients with breast cancer brain metastasis (BCBM). Therefore, the disease-free survival time, whether with or without visceral metastasis, KPS score, the presence of meningeal metastasis, and the number of brain metastatic lesions are independent influencing factors on prognosis of patients with BCBM.


Breast Cancer (BC), Brain Metastases (BM), Prognostic Factors, Nursing

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Bilen J, Liu N, Burnett BG, Pittman RN, Bonini NM. MicroRNA pathways modulate polyglutamine-induced neurodegeneration. Molecular Cell 2006; 24(1): 157-63.

Brookmeyer R, Johnson E, Zieglergraham K, Arrighi HM. Forecasting the global burden of Alzheimer's disease. Alzheimer’s & Dementia 2007; 3(3): 186-91.

Fenner MH, Possinger K. Chemotherapy for Breast Cancer Brain Metastases. Onkologie 2002; 25(5): 474-79.

Kocher M, Müller RP, Staar S, Degroot D. Long-term survival after brain metastases in breast cancer. Strahlentherapie Und Onkologie 1995; 171(5): 290-95.

Lin NU, Bellon JR, Winer EP. CNS metastases in breast cancer. Clin Oncol. Journal of Clinical Oncology 2004; 22(17): 3608-17.

Nieder C, Nestle U, Walter K, Niewald M, Schnabel K. Dose/effect relationships for brain metastases. Journal of Cancer Research & Clinical Oncology 1998; 124(6): 346-50.

Posner JB. Management of central nervous system metastases. Seminars in Oncology 1977; 4(1): 81-91.

Wroński M, Arbit E, Mccormick B, Wrónski M. Surgical treatment of 70 patients with brain metastases from breast carcinoma. Cancer 1998; 82(4): 1746-54.

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