DOI: 10.14704/nq.2018.16.6.1665

The Expression and Significance of Drain-derived Neurotrophic Factor (BDNF) and Its Specific Receptor Trk B in Colon Cancer Cells

Yi Liu, Lunhui Zhang, Liang Xu


This paper aims at analyzing the expression and significance of the brain-derived neurotrophic factor (BDNF) in colon cancer cells. The expressions of BDNF have been detected in both of the colon cancer cell lines and the normal intestinal epithelial cell lines. The Colon cancer cell line has a high expression of the Trk B while it has no expression for the BDNF. The normal intestinal epithelial cell line HIEC has no expression for BDNF and low expression for Trk B. The proliferation rate by the BDNF increases gradually along with its increasing concentrations. Under the same concentration condition, the tumor proliferation rate by swollen tyrosine kinase receptor B gradually increases over time. BDNF can facilitate the proliferation of human colon cancer cell lines.


Brain-derived Neurotrophic Factor, Specific Receptor B, Colon Cancer Cell

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