DOI: 10.14704/nq.2018.16.6.1672

Regulatory Mechanism of Circadian Clock in Cerebral Ischemia Reperfusion

Shaoqun Tang, Wei Huan, Fang Yang, Bin Li, Shanshan Cai


This paper aims to study the regulatory mechanism of circadian clock in cerebral ischemia reperfusion. It is investigated how well the sleeps of child patients with cerebral ischemia have been treated with neonates as study subjects. The core clock genes during the regulation of the circadian clock get explored by the bioinformatics methods. Here also analyzes pineal gland expression by combination with relevant technologies. The results reveal that the patients’ sleep quality has a stake in circadian rhythm and respiratory problems; the pineal gland can regulate the core clock genes in the circadian clock during the regulation. It is concluded that in relation to the treatment against ischemic diseases of neonates, sleep disorder and pineal function lesion require lucubrating to seek appropriate therapeutic regimen.


Circadian Clock, Cerebral Ischemia Reperfusion, Regulatory Mechanism

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