DOI: 10.14704/nq.2019.17.3.1989

How About P300 in Patients with Depression in China: Review of Results from Some Chinese Meta- Analysis

Shen Ying, Chen Fengpei, Zhu Jianfeng, Gao Zhhan, Ren Zhibin, Chen Zhenxin, Ma Yongchun, Jin Weidong


The depression are a common mental disorders in China. It's morbidity is about 4. 0/100, which influence Chinese people's mental health. The Chinese psychiatrists carry out many studies about depression in aetiology,therapeutics,prophylaxis and rehabilitation. The study of P 300 in patients with depression are one of those studies, and also generated some studies about relationship between P300 and depression. These studies include : (1) features of depression patients, (2) effects of antidepressants on P300 in patients with depression, (3) relationship between P300 and depression symptoms, (4) relationship between P300 and cognitive impairment, (5) treatment effective prediction role of P300 in patients with depression. (6) P300 aid in the differential diagnosis of subtype of depression. These results will be reviewed and assessed in our review.

Major depressive disorder is a serious mental disorder that profoundly affects an individual's quality of life. Although the aetiology underlying this disorder remain unclear, an increasing attention has been focused on the pathophysiological changes, regardless of etiology or outcome, which are associated with depression (Yang et al., 2015). The existence of such a link is indeed conducive to the study of the etiology of depression and the initiation of therapeutic. P300 also was studied widely in depression as a index of cognitive function, because most of patients with depression often are company with cognitive impairment. P300 waveform is the most widely used component of event-related brain potential (ERP), which is related to cognitive information processing, including working memory, attention and executive function. As an electrophysiological indicator of cognitive activity, P300 is non-invasive, inexpensive, convenient, and free of cultural and educational bias. Because of its high temporal resolution, P300 is more sensitive to cognitive changes than traditional neuropsychological tests and can provide insight into cognitive processes.


P300, depression, meta-analysis, Chinese data

Full Text:



Duan JG, Pan WM, Mu, JL Yuan XL, Zhang ZH. Cognitive function and Evevt Related Potential P300 Among Different Severity Depressive Patients. J Clin Psycho Med 2017; 27(5): 327-330.

Li Ronghua, Yang Yong, Feng Xiujuan, Yuan Xin, Du Xiangdong, Yang Yiqin. The study of P300 on patients with post-stroke depression:a systematic review and Meta-analysis. Journal of Sichuan Mental Health 2012, 25(2): 80-86.

Liu F, Yao LQ, Chen JH Therapeutic efficiency of acupuncture at baihui(GV 20)and Shenting (GV 24) for post-stroke cognitive impairment. Shanghai J Acu-mox 2018; 37(1): 104-111.

Lu Shuang. Event related potential P300 studies on cognitive function in Chinese first-episode, drug-naive depression patients:a meta-analysis. J Neur Dis and Ment Health 2014, 14(5): 477-483.

Rock PL, Roiser JP, Riedel WJ, Blackwell AD. Cognitive impairment in depression: a systematic review and meta-analysis. Psychological medicine 2014; 44(10): 2029-2040.

Shen Y and Wang W. Character of event-related potential P300 on depression of stagnation of liver Qi and deficiency of both heart and spleen. Zhejiang University, 2014.

Shen Y, Chen ZX, Jin WD, Ma YC, Wang W. Study on P300 in senile patients with depression:a meta-analysis of domestic literatures. Chin J Geriatr 2014, 33(11): 1235-1237.

Shen Y, Chen ZX, Jin WD, Wang W. Evidence-based medicine evaluation of P 300change in depression patients. J Clin Psynchosom Dis 2015, 21(2): 9-13.

Xirenguli Zineng and Kumusi Bayamaimaiti. Comparative Sturdies of Changes Visual ERP-P300 in Patients with Depression Before and After Treatment. Xinjiang Medicine University, 2017.

Xu JH, Shen Y, Chen ZX, Jin WD. EBM analysis of antidepressants effects on P300 in patients with depression. Chin J of Drug Evaluation 2013b, 30(3): 155-158.

Xu JH, Yao YH, Ma YC, Shen Y, Jin WD. Study on P300 in patients with post-stroke depression:meta-analysis of domestic data. J of Sichun Mental Health 2013a, 26(4): 328-331.

Yang L, Zhao Y, Wang Y, Liu L, Zhang X, Li B, Cui R. The Effects of Psychological Stress on Depression. Curr Neuropharmacol 2015; 13(4): 494-504.

Zhang Y, Tang W, Song XH, Zhang GY, Xu H. Systematic Review and Meta Analysis of the Efficiency of Acupuncture and Moxibution plus Cognitive Rehabilitation Training in Treating Post-stroke Cognitive Disorders. Shanghai J Acu-mox 2015, 34(10): 1030-1037.

Zhong BL, Xu YM, Xie WX, Li Y. Can P300 aid in the differential diagnosis of unipolar disorder versus bipolar disorder depression? A meta-analysis of comparative studies. J Affect Disord 2018; 245: 219-227.

Supporting Agencies

| NeuroScience + QuantumPhysics> NeuroQuantology :: Copyright 2001-2019