Vestibular Stimulation in Humans by Static Magnetic Fields of A 3T MRI Scanner – A Pilot Study
Methods: Twelve volunteers were included. The right eye gaze location was recorded during introduction of the subject to the 3T MRI scanner's bore and during a similar movement outside the MRI suite. From the raw data from eyetracker Arrington, deviation angles of gaze and angular velocities and another parameters of nystagmus were calculated.
Results: All subjects presented the changes in eye movements direction and strength during introduction to the scanner. In control conditions, obtained nystagmus was predominantly vertical- this domination disappeared in magnetic field. The results presented a significant inter-subject variability. Movement on the scanner's table resulted in a larger and faster change in the pupil's position in X and Y axes (P<0.02). Compared to standard conditions, magnetic field tended to stabilize the movement in Y axis (P<0.02). Statistical analysis showed that during 120 s of observation, the maximal nystagmus was noted in 52,2s; the minimal in 71,6s. Nystagmus did not disappear, its frequency was 0,45. The direction of nystagmus in MRI was predominantly horizontal.
Conclusions: Introduction of healthy individuals into an MRI scanner during custom clinical conditions results in a vestibular activation that is different from the same movement outside artificial magnetic field. However, the reaction presents a significant inter-subject variability.
Antunes A, Glover PM, Li Y, Mian OS, Day BL. Magnetic field effects on the vestibular system: calculation of the pressure on the cupula due to ionic current-induced Lorentz force. Physics in Medicine & Biology 2012; 57(14): 4477.
Glover PM, Cavin I, Qian W, Bowtell R, Gowland PA. Magnetic‐field‐induced vertigo: a theoretical and experimental investigation. Bioelectromagnetics: Journal of the Bioelectromagnetics Society, The Society for Physical Regulation in Biology and Medicine, The European Bioelectromagnetics Association 2007; 28(5): 349-361.
Glover PM, Li Y, Antunes A, Mian OS, Day BL. A dynamic model of the eye nystagmus response to high magnetic fields. Physics in Medicine & Biology 2014 Jan 17;59(3):631.
Gowland PA. Present and future magnetic resonance sources of exposure to static fields. Progress in biophysics and molecular biology 2005; 87(2-3): 175-183.
Heilmaier C, Theysohn JM, Maderwald S, Kraff O, Ladd ME, Ladd SC. A large‐scale study on subjective perception of discomfort during 7 and 1.5 T MRI examinations. Bioelectromagnetics 2011; 32(8): 610-609.
Heinrich A, Szostek A, Meyer P, Nees F, Rauschenberg J, Gröbner J, Gilles M, Paslakis G, Deuschle M, Semmler W, Flor H. Cognition and sensation in very high static magnetic fields: a randomized case-crossover study with different field strengths. Radiology 2013; 266(1): 236-245.
Jareonsettasin P, Otero-Millan J, Ward BK, Roberts DC, Schubert MC, Zee DS. Multiple time courses of vestibular set-point adaptation revealed by sustained magnetic field stimulation of the labyrinth. Current Biology 2016; 26(10): 1359-1366.
Liu F, Zhao H, Crozier S. Calculation of electric fields induced by body and head motion in high-field MRI. Journal of Magnetic Resonance 2003; 161(1): 99-107.
Mian OS, Li Y, Antunes A, Glover PM, Day BL. Effect of head pitch and roll orientations on magnetically induced vertigo. The Journal of physiology 2016; 594(4): 1051-1067.
Ngen E and Artemov D. Advances in monitoring cell-based therapies with magnetic resonance imaging: future perspectives. International journal of molecular sciences 2017; 18(1): 198.
Noguchi T. A technical perspective for understanding quantitative arterial spin-labeling MR imaging using continuous ASL. Polish journal of radiology 2016; 81: 317.
Oman CM and Young LR. The physiological range of pressure difference and cupula deflections in the human semicircular canal: theoretical considerations. Acta oto-laryngologica 1972; 74(1-6): 324-331.
Otero-Millan J, Zee DS, Schubert MC, Roberts DC, Ward BK. Three-dimensional eye movement recordings during magnetic vestibular stimulation. Journal of neurology 2017; 264(1): 7-12.
Roberts DC, Marcelli V, Gillen JS, Carey JP, Della Santina CC, Zee DS. MRI magnetic field stimulates rotational sensors of the brain. Current Biology 2011; 21(19): 1635-1640.
Schenck JF. Health and physiological effects of human exposure to whole‐body four‐tesla magnetic fields during MRI. Annals of the New York Academy of Sciences 1992; 649(1): 285-301.
Serafin Z, Strześniewski P, Lasek W, Beuth W. Time-resolved imaging of contrast kinetics does not improve performance of follow-up MRA of embolized intracranial aneurysms. Medical science monitor: international medical journal of experimental and clinical research 2012; 18(7): MT60.
Shaikh AG. A trail of artificial vestibular stimulation: electricity, heat, and magnet. Journal of Neurophysiology 2012; 108(1): 1-4.
Theysohn JM, Maderwald S, Kraff O, Moenninghoff C, Ladd ME, Ladd SC. Subjective acceptance of 7 Tesla MRI for human imaging. Magnetic Resonance Materials in Physics, Biology and Medicine 2008; 21(1-2): 63-72.
van Nierop LE, Slottje P, van Zandvoort MJ, de Vocht F, Kromhout H. Effects of magnetic stray fields from a 7 Tesla MRI scanner on neurocognition: a double-blind randomised crossover study. Occup Environ Med 2012; 69(10): 759-766.
Ward BK, Roberts DC, Della Santina CC, Carey JP, Zee DS. Magnetic vestibular stimulation in subjects with unilateral labyrinthine disorders. Frontiers in neurology 2014; 5: 28.