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Home > Archives > Volume 17, No 5 (2019) > Article

DOI: 10.14704/nq.2019.17.5.2369

Differences in Neurobiology of Different Syndrome of Melancholia in the Viewpoint of TCM

Sun Fengli, Liu Jie, Chen Fengpei, Zhu Jianfeng, Gao Zhihan, Ren Zhibin, Shen Ying, Chen Zhenxin, Ma Yongchun, Wang Zhiqiang, Jin Weidong


To some extent, melancholia in different Traditional Chinese Medicine (TCM) Syndromes represents different "subtypes" of depression. Whether bipolar depression or general depression, whether accompanied with or without psychotic symptoms, or with or without cognitive impairment, there are clinical and possible biological differences in these depressions, which indicates that different "subtypes" of depression represented by different TCM syndromes not only are different clinical syndromes, but also imply that there may be some biomarkers. The melancholia with liver depression and stagnation is different from melancholia with deficiency of both heart and spleen in clinical symptoms, which may indicate that there are differences in some potential biological biomarkers. For example, central nervous transmitters, trace elements, electrophysiology, neuroendocrinology, brain imaging, and even genomics may differ among different TCM syndrome types of depression, which not only serves for the modernization of TCM, but also finds biological differences for different TCM syndrome types of depression.


depressions, TCM, neurobiology

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