DOI: 10.14704/nq.2018.16.6.1640

Post-Stroke Neuroprotection and Repair of Astrocytes

Yuyan Jiang, Yinghao Zhi, Liangtang Guo, Yuyan Jiang


This paper aims to analyse the neuroprotection and repair of astrocytes after cerebral stroke. To this end, the activities of astrocytes under normal and hypoxia conditions were studied, and the glutamate uptake ability of cells was analysed by colorimetry. The results show that the glutamate uptake ability of astrocytes under both hypoxia and normal conditions can be inhibited by channel inhibitors. When cerebral hemorrhage is gradually prolonged, astrocyte proliferation is more and more obvious. Therefore, it is concluded that there is a close relationship between astrocytes and stroke; the cells proliferation shall have an effect on neuroprotection and repair, which needs to be inhibited by channel inhibitors.


Astrocyte, Neuroprotection, Nerve Repair

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Doyle KP, Simon RP, Stenzel-Poore MP. Mechanisms of ischemic brain damage. Neuropharmacology 2008; 55(3): 310-18.

Ikeda S, Harada K, Ohwatashi A, Kamikawa Y. Effects of edaravone, a free radical scavenger, on photochemically induced cerebral infarction in a rat hemiplegic model. The Scientific World Journal 2013; 2013(3): 175-80.

Johnston SC, Mendis S, Mathers CD. Global variation in stroke burden and mortality: estimates from monitoring, surveillance, and modelling. The Lancet Neurology 2009; 8(4): 345-54.

Kristián T, Siesjö BK. Calcium in ischemic cell death. Stroke 1998; 29(3): 705-18.

Martin RL, Lloyd HG, Cowan AI. The early events of oxygen and glucose deprivation: setting the scene for neuronal death. Trends in Neurosciences 1994; 17(6): 251-57.

Murray CJ, Lopez AD. Measuring the global burden of disease. New England Journal of Medicine 2013; 369(5): 448-57.

Siesjo BK, Hu B, Kristian T. Is the cell death pathway triggered by the mitochondrion or the endoplasmic reticulum. Journal of Cerebral Blood Flow and Metabolism Official Journal of the International Society of Cerebral Blood Flow and Metabolism 1999; 19(1): 19-26.

Warlow CP, Dennis MS, J. Van G. Stroke-A practical guide to management. Blackwell Science, 1996; 239(1556): 676-78.

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