DOI: 10.14704/nq.2019.17.7.2639

Research Progress of MicroRNA in Spinal Cord Injury

Yu Bao LU, Zong Yan Cai, Ge Ge He, Jia Yu Zhao, Yu Tong Chen, Shi Min Zheng

Abstract


Spinal cord injury (SCI) is a central nervous system disease with severe damage that causes partial or complete loss of movement and sensation below the injury segment, causing dysfunction. MicroRNAs (miRNAs) are a class of non-coding single-stranded RNA small molecules of approximately 18-25 nucleotides in length. Studies have shown that miRNAs play a regulatory role in the pathological process of spinal cord injury, which will provide a new target for the treatment of SCI. This article reviews the expression changes of microRNAs after spinal cord injury and the possible mechanisms of action in pathological processes.

Keywords


microRNA, spinal cord injury, regulation

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References


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Supporting Agencies

The Second Clinical School of Lanzhou University,



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