Introduction: Meningitis is a clinical syndrome characterized by inflammation of meninges. Encephalitis primarily involves the brain; it often involves the meninges as well (meningoencephalitis). This study is done to emphasize the importance of early diagnosis, so that prompt management is given at appropriate time. Aim: This is a prospective observational, single center study done in Department of neurologyGSVM medical college hospital Kanpur in 93 patients of acute meningoencephalitis cases: 1st March.2022 to 1st march 2024. The main aim of this study is ‘Study serum c-reactive protein levels as a monitoring tool in meningitis patients.’’ Materials And Methods: In the present study, we recruited 93 patients who presented with meningitis and meningoencephalitis who fulfilled the inclusion criteria. Proforma is used to collect data needed. Data are statistically analysed. Results: in this study, most of the patients were males and young adults. Surprisingly, tuberculous meningitis was the most common overall cause in our study. Tuberculous meningitis was the most common cause in patient with subacute meningitis. All patients with chronic presentation had tuberculous meningitis. 31 patient was found as bacterial meningitis which had s-crp value mostly ranging between >24 mg/l, out of them 19 patient had s-crp value >48 mg/l (61.29%). Most of them had poor prognosis and presented with altered sensorium and high-grade fever. most of the case out of 37 had s-crp value between intermediate range (12-48) mg/l and 2 patients had range between >48 mg/l which had miliary tuberculosis. Conclusion: Estimation of C-reactive protein in serum is the cheapest, sensitive and specific test to differentiate bacterial from viral infections. It is a simple qualitative as well as quantitative test and can be done as a bed side investigation. With serum C-reactive protein, a definite etiological diagnosis can be made rapidly at the time of admission itself.

c-reactive protein, meningo-encephalitis, tuberculosis.