Introduction–Serum calcium is an important mediator of cell damage after TBI and cellular hypocalcemia may have a neuroprotective effect after brain injury Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Traumatic brain injury (TBI), sometimes referred to as acquired brain injury, significantly increases death and lifetime impairment. Traumatic brain injury accounts for 25% to 30% of all accidental deaths and 27% of trauma-related hospital deaths (TBI). Background: The present study has been conducted to assess whether hypocalcaemia can be used as a prognostic factor in the outcome of traumatic braininjury. Materials And Methods: This prospective study was done on 100 patients with moderate to severe traumatic brain injury in trauma centre of nscb medical college Jabalpur from 2020-2022. Serum calcium levels of patients had a Glasgow coma scale of 3–13 points following traumatic brain injury, with demonstrable intracraniallesionsincranial computed to mography were included. Student's t test, chi square test and Fisher's exact test were used for comparative analysis. Logistic regression and receiving operative curves analysis analysis were also done to assess the risk factors. Results: Statistically significantdifference were found in the Ca2+levels on the 3rd day of admission between the patients with GOS ≤3 and the patientswith GOS>3 (P=0.029). The best level of higher sensitivity (86.27%) and specificity (68.66%) of hypocalcaemia on 3rdday was the Ca2+ value of 1.14 mmol/L. Conclusion: The serum Ca2+levels on day 3 could be useful for the prediction of mortality and disability in patients with moderate to severe traumatic brain injury.

Serum calcium is an important mediator of cell damage