Introduction: Encephalitis presents as diffuse or focal neuro psychological dysfunctional though it primarily involves the brain, it often involves the meninges as well (meningoencephalitis).Meningitis is a clinical syndrome characterized by inflammation of meninges. This study is done to emphasize the importance of early diagnosis, so that prompt management is given at appropriate time. Aim: This is a prospective observational, single center study done in Department of medicine NSCB medical college hospital Jabalpur in 93 patients of acute meningoencephalitis cases: 1st March.2020 to 31 August 2021. The main aim of this study is‘’To study the clinical profile, laboratory parameters and radiological investigations of acute meningoencephalitis patients’’ Materials And Methods: In the present study, we recruited 93 patients who presented with meningitis and meningoencephalitis who fulfilled the inclusion criteria. Proforma is used to collect data needed. Data are statistically analysed. Results: Among the 93 patients with meningo-encephalitis in this study. Most of them had poor prognosis and presented with altered sensorium and high-grade fever. On investigation we found that 0 = Normal, 1 = Meningeal Enhancement, 2 = Hydrocephalus, 3 = Granuloma, 4= Vasculitic infarct, 5 = Other findings (Thrombosis, Sinusitis, Icsol, Gliosis) found. Conclusion: In the present study we found that, most of the patients with meningoencephalitis were males and young adults. Tuberculous meningitis was the most common cause in patient with subacute meningitis. All patients with chronic presentation had tuberculous meningitis. We came across atypical presentation of cryptococcal meningitis in a non-HIV patient.47 patients recovered well without neurological deficits.

c-reactive protein, meningo-encephalitis, tuberculosis, vasculitis.