The current study's objective was to create a self-micro emulsifying drug delivery system (SMEDDS) for cardiovascular medications like verapamil hydrochloride in order to increase solubility, dissolution rate, which may improve therapeutic performance, and drug loading capacity in order to create an alternative to conventional oral formulations and increase bioavailability. Oleic acid, Tween 80, PEG 400, Castor oil, Labrasol, and Transcutol P were chosen as the oil, surfactant, and co-surfactant for VPH, respectively, in this study. The three formulations, designated VLM1, VLM2, and VLM3 for VPH, were successfully prepared after being chosen from the ternary phase diagram at Km value 3. A variety of criteria were assessed for prepared liquid SMEDDS. It was discovered from this investigation that all liquid SMEDDS formulations had globule size in the nanometric range, good stability with no phase separation, creaming, or cracking, and swiftly created micro emulsion that was clear with a faint blue tint.

Verapamil hydrochloride, Oleic acid, Labrasol, Transcutol P, smedds