With improvements in the detection limits and selectivities of ISEs, the introduction of new materials, new sensing concepts (from conventional potentiometry to dynamic electrochemistry approaches), and deeper theoretical understanding and modelling of the potentiometric responses of ISEs, potentiometry based on ion-selective electrodes (ISEs) has experienced a renaissance. The latest developments promote advancements in ion sensing and biosensing software. Additionally, by employing ISEs as potent transducers, flexible sensing methods have been developed for a wide variety of different target molecules in response to the introduction of new bioreceptors, including as enzymes, antibodies, aptamers, and pepetides. This study examines current potentiometric biosensor trends. There have been discussions about their uses in the biosensing of metal ions, tiny molecules, DNA, proteins, microbes, and toxins.Based on the combination of potentiometric ISEs with novel materials and cutting-edge methodologies, this review offers an outlook for potentiometric biosensing.

Ion-selective electrode, bioreceptor, potentiometric biosensing, and potentiometric biosensing