A method for synthesizing corticosteroid loaded hybrid nanoparticles to target alveolar macrophages, wherein the method comprises of: dissolving soya lecithin, ethyl cellulose and hydrocortisone separately in a beaker in lipid phase under continuous stirring followed by a magnetic stirrer; adding polyvinyl alcohol (PVA) solution in aqueous phase dropwise to the lipid phase containing hydrocortisone by stirring continuously for a defined interval by the magnetic stirrer followed by sonication to prepare a hybrid formulation, wherein the hybrid formulation is lyophilized; and coating the prepared hybrid formulation with Carubinose in acetate buffer medium, wherein the carubinose coating buffer solution is eventually mixed with the lyophilized formulation under continuous stirring for 1-1.5 hour[1].

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