Volume 20 No 22 (2022)
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A Composition And A Method For Synthesizing Corticosteroid Loaded Hybrid Nanoparticles
Mr. Brijesh Kumar Saroj, Miss. Sarita, Dr. Akhilesh Patel, Mr. Saurabh Jawahar Sanghavi, Mr. Lalit Sharma, Dr. Raveen Chauhan, Mrs. Anjali Saini, Mr. Soumik Laha
A method for synthesizing corticosteroid loaded hybrid nanoparticles to target alveolar macrophages, wherein the method comprises of: dissolving soya lecithin, ethyl cellulose and hydrocortisone separately in a beaker in lipid phase under continuous stirring followed by a magnetic stirrer; adding polyvinyl alcohol (PVA) solution in aqueous phase dropwise to the lipid phase containing hydrocortisone by stirring continuously for a defined interval by the magnetic stirrer followed by sonication to prepare a hybrid formulation, wherein the hybrid formulation is lyophilized; and coating the prepared hybrid formulation with Carubinose in acetate buffer medium, wherein the carubinose coating buffer solution is eventually mixed with the lyophilized formulation under continuous stirring for 1-1.5 hour[1].
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