


Volume 20 No 10 (2022)
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A Comprehensive Review on Monkeypox Virus Transmission, Pathogenesis, Treatments and its Preventive Measures
Anil K. Yadav , Ashish Srivastava , Priyanka Verma , Parul Srivastava , Divyanshi Gupta , Zulfa Nooreen
Abstract
As the threat of a coronavirus disease 2019 (COVID-19) pandemic subsides, governments throughout
the world are dealing with epidemic concerns due to the occurrence of monkeypox cases in various
areas. Previously limited to African countries, the majority of monkeypox cases associated with the
2022 epidemic have been recorded in countries throughout Europe and the Western Hemisphere.
While multiple organisations are doing contact-tracing operations, it is still unclear how this
outbreak began. Monkeypox virus is one of several zoonotic viruses in the Orthopoxvirus genus of
the Poxviridae family. Following the universal abolition of smallpox in the 1970s, monkeypox
outbreaks drew international attention.The smallpox immunisation provided immunity against the
monkeypox virus. Monkeypox cases rose when smallpox vaccine was halted. It wasn't until the 2003
US pandemic that monkeypox became well known. The virus did not originate in monkeys, despite
the name "monkeypox." Although other rodents and small animals have been recognised as the
virus's origins, the precise origin of monkeypox is uncertain. The viral infection was originally
observed in macaque monkeys, thus the term monkeypox. Although human-to-human transmission
of monkeypox is exceedingly rare, it is usually associated with respiratory droplets or direct contact
with infected people's mucocutaneous sores. There is presently no treatment available for infected
people; however, supportive therapies can be utilised to relieve symptoms; drugs such as
tecovirimat may be used in severe cases. Many therapy are subjective since there are no
unambiguous guidelines for symptom relief.
Keywords
Orthopoxvirus, Poxviridae, Monkeypox, Zoonotic Disease, Corneal infection
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