Volume 22 No 5 (2024)
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A Cross-Sectional Study of Prognostic Importance of Lipid Profile, Plasma Glucose Level, and HbA1C Levels in Patients with Acute Ischemic Stroke
Dr. Arunim Shikhar, Dr. Kamal Kant Adile, Dr. Ram Gopal Ghritlahare, Dr. Chandra Mohan Singh
Abstract
BACKGROUND In India, stroke is a serious medical condition that frequently results in emergency admissions. People who have a stroke frequently experience higher rates of morbidity, mortality, & reduced quality of life. Among the risk factors for stroke are metabolic disorders like DM (diabetes mellitus) & dyslipidaemia. Acute stroke stress can manifest as hyperglycaemia, which in people without DM history might indicate undiagnosed DM or stress hyperglycaemia. METHODOLOGY This cross-sectional study was performed in a teaching hospital over the course of a year. Acute stroke patients who were hospitalized within three days of the stroke episode & who satisfied additional study inclusion requirements were progressively enrolled. Biochemical evaluations & clinically pertinent data were recorded within 3 days of hospitalization. Blood glucose, glycosylated haemoglobin (HbA1c), as well as lipid profile tests were performed at presentation. An irregular lipid profile, stress hyperglycaemia, undiagnosed DM, & a prior history of DM were observed. The statistical tests employed were Chi square as well as Student's t test. RESULTS Of the 130 stroke patients who were enrolled, 76 percent satisfied the requirements for ischaemic stroke. Mean age & age range of Study subjects had been 54.4yrs. According to their glycaemic status, the study participants were divided into four groups: stress hyperglycaemia, euglycaemia, DM, & previously undiagnosed diabetes mellitus. In 5th decade of life, stress hyperglycaemia was common & equally prevalent in people who had haemorrhagic as well as cerebral stroke. Low HDL & increased LDL-C were the most frequent lipid abnormalities. CONCLUSIONS Upon detection of an abnormal metabolic environment, there exists a critical opportunity for assertive intervention, which will enhance outcomes for stroke patients. Using blood glucose as well as glycosylated haemoglobin tests, routine screening for hyperglycaemia in stroke patients may reveal previously undetected DM.
Keywords
Cerebrovascular Diseases, Glycosylated Haemoglobin, Stroke, Aneurysms.
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