Objective: To determine the efficacy of Doxycycline for pleurodesis in cases of malignant pleural effusions. Material and Methods: The design of this study was descriptive case series. This study was conducted at Allied Hospital Faisalabad and the duration of this study was from May 2022 to November 2022. In this study the diagnosed cases of malignant pleural effusion, irrespective of its type and metastasis in adult age range were included of both genders. The pleural effusion was effectively drained with appropriate chest drain. After complete drainage assessed by X ray chest PA view, 10 capsules of Doxycycline (100 mg) were diluted in 50 ml normal saline and were injected through chest drain and clamped for 24 hours. Paracetamol was given as analgesia. The drain was re opened after 24 hours and were followed by X ray chest to label for any fluid presence. Efficacy was lapelled as yes where there was no fluid on x ray and drain output was less than 50 ml.

Doxycycline, Pleurodesis, Malignant Pleural Effusion, Saline, Epidemiological, Transudative, Exudative