A Genetic Study on Association of Apolipoprotein E (Apo E) Gene Polymorphisms In Primary Open Angle Glaucoma Patients In Northern India

Volume 20 No 17 (2022)

Dr. Pankaj Baranwal, Dr. Rohit Shahi, Dr. Anjali Singh, Dr. Sony Chaudhary, Dr. Tanmay Srivastav, Dr. OPS Maurya

DOI: 10.14704/Nq.2022.20.17.Nq880112

Abstract

Aim: The main aim of study was to investigate the association between Apolipoprotein E (APOE) gene and primary open-angle glaucoma (POAG) in a cross sectional study of North Indian population. Method: The study included 23 cases (17 men, 6 women) and 27 controls (21 men and 6 women) who underwent systematic examination of optic disc, visual field examination with automated static perimetry, Intraocular pressure (IOP) measurement with Goldmann applanation tonometry and retinal nerve fibre layer thickness with Spectral domain Optical coherence tomography. Cases and control were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and polymorphisms of APOE gene were noted.

Keywords

Primary Open Angle Glaucoma, APOE gene, Gene Polymorphism, Intraocular Pressure

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