Background: Approximately a third of the world's population is infected by Toxoplasma gondii, which is the most common neurotrophic parasite, with seroprevalence rates that range from 10% to 80% to 95% in low and high prevalence countries. Toxoplasma gondii seroprevalence was examined in 100 Egyptian patients with disorder in this study, which compared clinical features between those who were seronegative and those who were positive for the parasite. Methods: A commercially available electrochemiluminescence immunoassay (ECLIA) kit named "Toxoplasma IgG& IgM" was used to measure antitoxoplasma antibodies IgG/IgM serum levels in fifty patients diagnosed with bipolar I disorder according to DSM-4 criteria (Creative Biolabs invitro diagnostics, Shirley, NY11967, USA). Results: 22 patients (44%) possessed anti–T. gondii IgG antibodies, with a mean Toxoplasma IgG level of 52.30 100.55 IU/L and a range of (0-400) IU/L. only one of the Toxoplasma-positive individuals was experiencing an acute infection. Patients above the age of 30 had a greater seroprevalence than those between the ages of 18 and 29. (59.1%vs. 40.9%) however this wasn’t statistically significant. No significant association was detected between T. Gondii and a specific type of current episode. Conclusion: individuals with IgG anti–T. gondii had fewer overall bouts of illness, had a shorter duration of illness than seronegative patients with an earlier age of onset. Patients with a history of both manic and depressive episodes had a greater percentage of IgG anti–T. gondii antibodies. The seronegative status was higher among current mania with psychotic symptoms group; however these results were insignificant statistically. These preliminary findings appear to rule out a link between chronic toxoplasmosis and bipolar disorder.

toxoplasma, bipolar disorder, clinical characteristics, Egypt , ECLIA