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Volume 20 No 6 (2022)
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A New ValidatedUPLC-MS/MS Method for the Determination of Carvedilol and 4'-hydroxyphenyl carvedilol in Rat Plasma: Pharmacokinetic and Bioequivalence Application
Saurabh Maan , RoopKrishenKhar,,RupaMazumder , Urooj Ahmed Khan ,Nishant Yadav , Mohammad
Abstract
A selective, simple, sensitive and rapidUltra-performance liquid chromatographic tandem mass spectrometric (UPLC-MS/MS) method for the detection of Carvediloland 4'-hydroxyphenyl carvedilolin rat plasma has been developed and validated using Carvedilol-D5 and 4'-hydroxyphenyl carvedilol-D5 as Internal Standards (IS) respectively
Keywords
Carvedilol;Mass Spectrometric; Rat Plasma; Ultra Performance Liquid Chromatographic
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