The present investigation was intended to explore certain Lovastatin producing soil fungi from forest regions of Pachmarhi Bioreserve of M.P in Central India. Many microorganisms survive in soil and produce enthralling and structurally complex bioactive products of pharmaceutical importance. Lovastatin is an interesting fungal metabolite and world widely prescribed drug to combat hypercholesterolemia. Commercially, lovastatin is produced by Aspergillus terreus. Due to high cost of production poses the need to investigate and screen out the potent lovastatin producer fungal species from the unexplored outreaches. Soil sampling was collected from the outer skirts of Pachmarhi Town in November 2020 which was used for serial dilution and cultured on PDA media plates for raising fungal colonies. The developed colonies were counted and pure cultured were subjected to screening of lovastatin production by yeast inhibition model. The promising fungal isolates were used for fermentation activity in Czapek yeast extract (CzYE) culture broth at 27oC in a BOD incubator for 5 days in shaking condition at 60 rmp.

Pachmarhi Bioreserve, Lovastatin, Aspergillus spp, HPLC.