Skin wound restorative is an intriguing mechanism and characterizes an evolutionary advantage not only for mammals. Due to its vital functions as a corporeal, biological and microbial barrier, skin wound healing is a significant step for survival concluding in wound termination. Wound healing is an unmet healing challenge among medical people since wound assessment and management is a complex process including several factors playing main role in healing though some connections during the healing process are dangerous, termination is high and other cells or mediators can adopt functions or signaling without major difficulties process. Collagen is fundamentally and functionally a key protein of the extracellular matrix which is also involved in scar construction during the healing of connective tissues

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