Steroidal and nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used treatments in chronic inflammatory diseases. However, long-term use of NSAIDs leads to serious side effects. In this study we aimed to assess the anti-inflammatory potential of seed parts of Abelmoschus moschatus. Seeds ofA. moschatuswassubjected to successive solvent extraction by continuous hot extraction (Soxhlet) with 50% methanol(Extract I) and 50% ethanol (Extract II). The in-vitro anti-inflammatory activity of both aqueous methanolic and ethanolic seed extracts of A. moschatus was determined using albumin denaturation method. Results revealed that there was dose dependent inhibition (%) was observed in standard as well as Extract I and Extract II of A. moschatus. Furthermore, the inhibition (%) of Extract I and Extract II of A. moschatus at the concentration of 500 µg/mL was at par with that of standard drug i.e., Aspirin. The major phytochemicals found in Extract I and Extract II of A. moschatuswere found to be flavonoids, glycosides, phenolic compounds, and tannins. Phenolic quantity was found to be highest in both Extract I (6.45 GAE) and Extract II (3.65 GAE) as compared to flavonoid and tannin quantities. In conclusion, results of the preset study demonstrated the anti-inflammatory potential of aqueous methanolic and ethanolic extracts seed extracts of A. moschatus and hence they could be exploredin the development natural anti-inflammatory drugs

Abelmoschus moschatus, Anti-inflammatory potential, Extracts, Phenolic compounds, Flavonoids, Tannins