Benzimidazole is an aromatic heterocyclic chemical molecule. The pharmacological actions of various molecules produced from the benzimidazole nucleus vary. Antivirals, antimicrobials, anticancer, antiparasitic, antioxidants, proton-pump inhibitors, anti-inflammatory, anticoagulants, antihypertensives, immunomodulators, and other therapeutic medications contain the benzimidazole nucleus. The substitution pattern around the nucleus of numerous benzimidazole derivatives with distinct pharmacological activities is detailed to assist medicinal chemists in creating a SAR on benzimidazole-derived drugs for each activity. Because of their similarity to naturally occurring nitrogenous bases, such as purine, benzimidazole and its derivatives demonstrated a extensive spectrum of biological uses. The current review focuses on the chemistry and pharmacology of substituted benzimidazoles.

Benzimidazole, Heterocyclic Chemistry, Therapeutic Uses