Considering the high prevalence of Methamphetamine dependence and its severe complications, the risk factors and various factors in the tendency to substance should be investigated. Therefore, the aim of the present study was to predict methamphetamine dependence based on psychological and brain-behavioural system features. In this correlational descriptive study, 100 of all eligible methamphetamine dependents admitted in Farabi Hospital, Kermanshah, Iran in 2016 and 100 healthy persons were selected as the control by convenience sampling method. Data were collected from the self-report psychometric questionnaire (SCL-90) and Carver & White’s Brain- behavioural Questionnaire, and were analyzed by discriminant analysis. The coefficients of the audit function indicated that discordance, obsession, anxiety and sensitivity in relationships had the most roles in the diagnostic function, and the variables of impulsivity, paranoid, and novelty seeking had the lowest role in diagnostic function and its success. Also, the discriminant analysis method showed that the linear combination of the above variables can explain about 85.3% of the variance difference between two groups. According to the study findings, it is recommended that in prevention, treatment strategies, the role of psychological and brain-behavioural system features consider.

psychological, brain- behavioural system, methamphetamine, dependence