Osteoarthritis causes degenerative changes in the joints i.e. “wear and tear” resulting in pain and impaired function. Pathological cartilage loss occurs due to imbalance in the catabolic& anabolic mechanisms of cartilage remodeling. A Transdermal Delivery of Drugs is a unique method of delivering medicinal agents into the bloodstream via the skin's surface. The primary purpose for developing these is to create a novel medication delivery system that helps to reduce drug retention, metabolism, and fluctuation through the skin. Ethanolic extract of Cissus quadrangularis:Nigella sativa (80:20) ismore efficient in treating osteoarthritis hence same combination was used in formulation of transdermal patch. The patches were prepared by solvent evaporation method and by using HPMC (Hydroxypropyl methylcellulose), Ethyl Cellulose (EC), DibutylPhthalate, Ethanol and chloroform. HPMC is freely water soluble, whereas EC is hydrophobic. So the transdermal delivery systems were prepared using HPMC and EC to study the effect of hydrophilic and hydrophobic nature of polymer on release of drug. Developed Patch formulation was evaluated by considering parameters such as organoleptic characteristics, weight uniformity, thickness, drug content, folding endurance, tensile strength , percentage of moisture content & in-vitro permeation study. Formulation TF 2 Was found to be most effective as compared to others. Osteoarthritis activity of Transdermal Dermal patch was evaluated by using collagenase type II-induced osteoarthritis (CIOA) rat model. Out of six formulation TF 2 Was found to be most effective in osteoarthritis as compared to others.

Osteoarthritis,Transdermal Delivery of Drugs, Cissusquadrangularis andNigella sativa