Volume 20 No 9 (2022)
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A study ofserum cortisol levels in psoriasis and its association with the severity of the disease
Syeda Noorulain , Athyusha Korvi , Dr. Sai Sailesh Kumar Goothy
Abstract
Psoriasis is a chronic inflammatory, skin disease that is characterized by hyper-proliferation of
keratinocytes and inflammatory infiltration in the epidermis and dermis. Genetic, environmental, and hormonal
factors have been implicated inthe etiopathogenesis of the disease. Glucocorticoids (GC), released as cortisol is a
stress-response hormone with potent immunoregulatory mechanisms. It was hypothesized that loss of effective
skin-GC synthesis would form a pathogenic mechanism of psoriasis.
Keywords
Psoriasis, stress, cortisol.
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