Supramolecular chemistry, focusing on non-covalent interactions between molecules, has emerged as a dynamic field with broad implications across various disciplines. This review explores recent advancements in supramolecular chemistry, encompassing key areas such as host-guest chemistry, supramolecular polymers, catalysis, molecular machines, and interdisciplinary applications. Beginning with a historical overview and foundational principles, the paper discusses recent innovations including organocatalysis, metal-organic frameworks (MOFs), and applications in nanotechnology and medicine. Furthermore, it examines the role of supramolecular chemistry in addressing challenges in environmental sustainability, materials science, and biological systems. Highlighting current challenges, future directions, and potential innovations, this review underscores the transformative potential of supramolecular chemistry in advancing technological frontiers and addressing global challenges.

Supramolecular chemistry, host-guest interactions, supramolecular polymers, catalysis, molecular machines, nanotechnology, organocatalysis, metal-organic frameworks (MOFs), drug delivery, environmental applications.