Volume 20 No 12 (2022)
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ANTI-HYPERLIPIDEMIC AND ANTI-DIABETIC ACTIVITY OF PINITOL ISOLATED FROM WHOLE PLANT GLYCINE MAX
P. Sudhakar,Shobha Rani Satla , A Rama Narsimha Reddy
Abstract
Pinitol shows glycemic control by enhancing pancreatic insulin release and improving insulin resistance. In the present study, we have identified pinitol effect on blood glucose and cholesterol. The pinitol impact on lipid and glucose metabolism was studied in fatty Sprague Dawley rats. Treatment with 3-O-methyl-D-chiro-inositol significantly reduced triglyceride, total cholesterol, and LDL levels. Dose-dependent effects were observed with pinitol compared with 125mg/kg and 250 mg/kg doses. Total cholesterol levels in hyperlipidemia induced by olive oil were reduced in a significant manner. An oral glucose tolerance test was conducted in fatty and lean rats pinitol pretreated showed a substantial reduction in glucose levels after 2 hours (21%)in the fatty rats compared to the control animals. The present study emphasizes an anti-hyperlipidemic effect of pinitolin in the rat model, possibly by the inhibition of synthesis of VLDL
Keywords
Pinitol,antihyperlipidemic&hypoglycemicactivity, Glucose tolerance
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