Hypothyroidism is marked by increased levels of thyroid stimulating hormone and decreased levels of T3 and T4. Hypothyroidism reduces the basal metabolic rate leading to slowed down metabolism which is a result of imbalance in calorie consumption i.e. more calories being consumed than expended, this imbalance in turn leads to weight gain resulting in hypothyroid obesity more prevalent in woman above 30 years of age. Alteration in mice body weights were recorded after administering them Methimazole (0.025% hypothyroid inducing drug) orally in their drinking water for 21 days then for the next 21 days, group 3 was administered standard drug (Thyroxine), and group 4 was administered Momordica Charantia alcoholic extract and rest both the groups were administered normal food and water. Every group contained 6 mice and mice were divided into 4 groups. Mice were weighed at the starting of the experiment and reweighed every 7th day and water and food intake was observed throughout the study period. At the end of the experiment the weight changes on final day were analyzed by comparing with the initial day. Weight alterations were recorded to be significant and p*˂0.01 in the experimental mice. The mice were sacrificed at the end of the experiment and their liver was dissected out and histopathological studies were done on it to study the hypothyroid obesity linked changes in it. The experiment lead to the conclusion that the body weight of the experimental mice had increased due to induction of hypothyroid obesity and the Momordica Charantia alcoholic extract was effective in treating it and decreasing the mice body weight. The histological studies revealed the appearance of fatty vacuoles throughout the liver in the disease group and the Momordica Charantia alcoholic extract was able to reverse these changes successfully to a great extent.

Body weight, Hypothyroid obese, Swiss albino mice, Methimazole, Alteration