Cell-based treatments have been said to have considerable promise for the healing of wounds especially for those which don't heal or heal with severe scarring. Stem cells have been demonstrated to speed up the healing process by direct integration into regenerated cells and transformation to parenchymal cells. The downside of using stem cells include low probability of MSC survival, engraftment, and the quantity of newly created cells, through cell differentiation or fusion. Stem cells secrete a wide spectrum of physiologically active molecules, including cytokines, growth factors, mRNAs, and active lipids with crucial roles in skin tissue regeneration. MSC secretome and MSC-exosome are products of MSCs discharge, imitating the actions of parental MSCs. They have a great potential to be used as a non-cellbased therapeutic strategy for the management of various wounds that would avoid the adverse effects of stem cell therapy.

Exosomes, Secretome, Cutaneous, Novel, Treatment