A medicinal herb of the Zygophyllaceae family-Tribulus terrestris is home to many countries (India, Sudan, South Africa, Sudan, Europe, and China) in the form of weed. Though this traditional herbal plant has several regional and vernacular names but is known as Gokhru in Hindi in India. This plant has played a pivotal role in the Chinese and Ayurveda folklore medicinal system. This plant played an integral role in treating fertility issues, impotence, and erectile dysfunction in conventional age-old treatment therapies in China and India as its fruits and leaves were used as a diuretic in the Chinese and Indian medicinal systems. Owing to the presence of a plethora of active phytoconstituents such as steroidal saponins, flavonoids, tannins, and phenolic compounds this plant is widely under exploration. TT has been explored by herbalists worldwide and clinically proved its efficacy in the treatment of human ailments. This current review aims to summarize (2003-2021) in vitro and in vivo studies carried out on any segment of Tribulus terrestris along with the phytochemistry of active constituents present in it. This review may invite herbalists to approach forward with exploring molecular mechanisms related to phytoconstituents of TT for targeting diseases

Tribulus terrestris, Traditional medicine, pharmacologically active, Phytoconstituents