Introduction: The corpus callosum is the largest and the primary commissure of the brain connecting the left and right cerebral hemispheres.It integrates and transfer information from both cerebral hemispheres to process sensory, motor, and high-level cognitive signals. MRI is rapidly becoming an important tool for assessing corpus callosum. Establishment of normal parameters will help in diagnosis as well as treatment of various disorders. Objectives:To track the development of corpus callosum and explore the sexrelated and age related differences in various age groups. Material and methods: In a cross-sectional retrospective study, a sample of 100 healthyindividuals, in a tertiary care hospital were segregated into various subgroups –infants(0-2),children (2-10), adolescent (10-18), young adult (18-25),middle age adults(25-45),older adults (45-65) and elderly (65 and above).The size of CC was measured onmidsagittal section in T1 images (TR-450ms and TE- 8.7ms) on 1.5 Tesla SeimensMagnetom scanner.The cross-sectional area of seven segments ofthe CC– rostrum , genu , rostral body , anterior midbody , posterior midbody , isthmus andsplenium were calculated and correlated with brain dimensions: AB ( maximum longitudinaldimension), CD (maximum vertical dimension) and EZ( total longitudinal dimension of CC). The data was assessed using Spearman correlations, Anova tests and Mann-Whitney tests. Results: There was significant effect of age groups on the dimensions of various segments of CC. While no significant effect was observed of gender on the dimensions of corpus callosum. The brain dimensions: AB and CD tend to be smaller in women. The brain and corpus callosum both decreased in size with age. There was significant intersegmental correlation of brain and CC dimensions. Conclusions: MRI is a valuable and easily available modality for assessment of development of corpus callosum. The study will help in forming normal database for corpus callosum, for studying and diagnosing various disease processes.

The corpus callosum is the largest and the primary commissure of the brain connecting the left and right cerebral hemispheres.