Volume 20 No 12 (2022)
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Annexin A2 (ANXA2) In Colorectal Cancer
Yasmen Mohamed Mousa , Abdelbary EH , Doaa Abdelaziz Ibrahim , Mona Mostafa Ahmed
Abstract
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death. The prognosis of CRC usually depends on staging. However, a complex interaction of pathological features, clinical factors and molecular markers help in guiding prognosis and therapy. Identification of new markers and underlying molecular pathway of cancer development and progression will improve treatment response in cancer. Annexin A2 (ANXA2) belongs to a family of calcium-dependent phospholipid and membrane binding proteins called annexins. High ANXA2 expression has been detected in various tumors as CRC, gastric cancer, hepatocellular carcinoma, and ovarian cancers. Annexin A2 is essential in repair of injury in the normal colorectal epithelial cell. ANXA2 expression is increased in CRC compared to normal colonic tissue, that is why it is supposed that it has a role in colon cancer malignant transformation. The association of high ANXA2 expression with poor tumor pathologic features indicates its role as poor prognostic factor as it is involved in tumor proliferation, adhesion, angiogenesis, progression and invasion. In this review , we summarize structure, subcellular localization , mode of action and roles of ANXA2 ,as well as therapeutic techniques targeting ANXA2.
Keywords
Colorectal cancer; Annexin 2; immunohistochemical expression
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