Volume 20 No 22 (2022)
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Antibiotic Resistance in Paediatric Patients
Mohammad Azeem , Namita Arora , Pankaj Arora , Ume Kulsum , Rolla Mohammed Ahmad Alfahhad
Abstract
The threat of antibiotic resistance to public health is of the utmost concern, particularly for young children. According to data from the WHO, infections brought on by multidrug resistant bacteria result in 700,000 deaths worldwide each year, including about 200,000 infant deaths. The multifaceted roots of this escalating problem are unique to children's ages.Lack of pediatric-specific data and trials also contributes to the problematic abuse and misapplication of antibiotics including incorrect diagnoses and indications, or at the incorrect dosage. The constantly changing nature of this age group also raises another problem: the partly age-dependent variations of aevolving system of cytochromes regulate a rather assorted population in terms of biochemical traits and pharmacokinetics profiles, making it challenging to easily codify in an age- or weightdependent dosage.The current clinical and molecular information on paediatric antibiotic-resistant bacterial infections is highlighted in this article, with a focus on communicable resistance and spread via horizontal gene transfer.
Keywords
anti-microbial resistance, paediatric, antibiotics, epidemiology
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