Introduction: Rotator cuff tendinopathy presents challenges in management due to its prevalence and varied manifestations. Conventional treatments often provide temporary relief without addressing underlying pathology. Platelet-rich plasma (PRP) therapy emerges as a promising intervention, yet its efficacy remains debated. This study aims to evaluate PRP therapy's effectiveness compared to conventional treatments for rotator cuff tendinopathy. Objectives: This study compares PRP therapy versus conventional treatments in reducing pain intensity and improving shoulder function and patient-reported outcomes among individuals with rotator cuff tendinopathy. Materials and Methods: A prospective, randomized controlled trial was conducted involving patients aged 18-65 years with confirmed rotator cuff tendinopathy. Participants were randomized into PRP therapy or control groups. Outcome measures included pain intensity (VAS), shoulder function (Constant-Murley score), and patient-reported outcomes (ASES score, SPADI). Statistical analyses were conducted using SPSS version 22.0. Results: Baseline characteristics between groups were comparable. PRP therapy demonstrated significant pain reduction compared to conventional treatments at 6, 12, and 24 hours post-intervention (p < 0.05). Additionally, the PRP group showed significantly better shoulder function and patient-reported outcomes compared to the control group (p < 0.001). Multivariable regression analysis confirmed the superiority of PRP therapy even after adjusting for potential confounders (p < 0.01). Conclusion: PRP therapy demonstrates efficacy in reducing pain and improving shoulder function and patient-reported outcomes in individuals with rotator cuff tendinopathy. Further research is warranted to validate these findings and refine treatment guidelines.

Rotator cuff tendinopathy presents challenges in management due to its prevalence and varied manifestations.