Association of MEG3 Hypermethylation and MiR-21 Upregulation with the Incidence in Iraqi Acute Myeloid Leukaemia Patients

Volume 19 No 6 (2021)

Noha Mohammed Saleh, Hameed Majeed Jasim

DOI: 10.14704/nq.2021.19.6.NQ21077

Abstract

Background: Acute myeloid leukaemia (AML) can be defined as a hematologic malignancy that distinguished by genetic defects and epigenetics alterations. LncRNA MEG3 was shown to play the role of tumour suppressor, and play a pivotal role in leukemogenesis, MEG3 hypermethylation has been reported to be related to different types of haematological malignancies. MIR-21 is regarded as a significant miRNA, it considered to play a vital role in AML progressions

Keywords

MEG3, MiR-21, DNA Methylation, AML, Epigenetics

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