Astaxanthin upregulates Nrf2 in methotrexate-induced liver injury

Volume 20 No 7 (2022)

Sarah Saad Hamdan, Yassir Mustafa Kamal, Huda Jaber Waheed

DOI: 10.14704/nq.2022.20.7.NQ33090

Abstract

Methotrexate use in the treatment of cancer, rheumatoid arthritis, psoriasis and several other diseases is greatly limited due to its hepatotoxic effect. This poses a major problem for patients where no alternative drugs are present. The present study aimed to assess if this could be solved by the use of a potent antioxidant; astaxanthin

Keywords

Methotrexate, astaxanthin, Nrf2, ELISA and RT-PCR

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