Aim of Study:To evaluate biochemical parameters for diagnosis of Multisystem inflammatory syndrome in children (MIS-C) Background :MIS-C, also known as Pediatric Inflammatory Multisystem Syndrome Temporally related with SARS-CoV-2 (PIMS-TS), is a hyperinflammatory syndrome in children. • The syndrome has a close temporal association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. • Cases in India were reported in May 2020, and the prevalence has increased with the rise in COVID-19 cases across the nation. • Clinical Presentation: • Children with MIS-C may develop inflammatory conditions post-infection rather than during the acute infective stage of COVID-19. • While clinical symptoms in children are generally milder than in adults, a proportion of children require hospitalization and pediatric intensive care. Method: The Paediatrics Department of the NKPSIMS Medical College in Nagpur has undertaken the observational research. From March 2021 to October 2023 , all kids diagnosed with MIS-C who were hospitalised to our hospital between the ages of 1 month and 18 years were included in the research. All blood tests and inflammatory indicators were examined in all MIS-C patients, and the severity of the condition was treated in accordance with the findings. Results: Twenty kids were diagnosed with MIS-C following a COVID infection. All kids who met the MIS-C requirements had biochemical evaluations including all blood tests and indicators of inflammation. Increased levels of inflammatory markers were closely associated with severe MIS-C patients. Most instances were mild to severe cases, and they were all treated in accordance with their sickness categorization. One death fell into category 4. Conclusion:The severity of MIS-C in children was correlated with inflammatory indicators in this study, which will offer insights into current therapeutic management and implications for immediate future research initiatives.

Inflammatory markers, MIS-C, pandemic , covid-19 , severity.