Since enzyme-powered micro/nanomotors have demonstrated excellent biocompatibility and bioavailability, as well as the ability to transform chemical energy into mechanical work even in ionic settings, they have sparked considerable interest in the field of hybrid micro/nanomotors. They have enabled active targeting, cargo loading and release, and biosensing, all of which are made feasible by the complex design and functionalization of their devices. Comprehensive understanding of structural complementary domains and synergistic interactions will provide unique characteristics for the bottom-up self-assembling of numerous enzymes in the development of bioinspired biomolecular machines in future concepts, such as the development of bioinspired biomolecular machines. The movement of enzyme-powered nanorobots will be controlled by a concentration gradient in a certain direction. If they are used in medical applications, they will move in reaction to a chemical gradient generated at the site of tissue damage or inflammation. CAT-powered poly (lactic-co-glycolic acid) micromotors that move in response to a hydrogen peroxide concentration gradient for the delivery of a periodontal disease treatment were recently published in a study by Wilson and colleagues. 64 In an in vitro model of inflammatory periodontitis, a phorbol ester activated macrophage cell was employed to investigate the chemotactic self-propulsion of micromotors

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