Biological evaluation of some methyl 2-((4-acetylthiazol-2- yl)sulfanyl)-1,2,3,4-tetrahydro-6-methylpyrimidine-5- carboxylate derivatives as potential DHFR inhibitors to overcome antibiotic resistance

Volume 20 No 7 (2022)

Sherkhan Pathan, Mazahar Farooqui, Suparna Deshmukh

DOI: 10.14704/nq.2022.20.7.NQ33151

Abstract

Multidrug-resistant bacteria are an increasing global threat. Current therapeutic medicines aren't enough to meet the demand. To address antibiotic resistance, new targets and inhibitors are needed. Dihydrofolate reductase (DHFR) is essential for bacterial development, hence DHFR inhibitors are helpful in treating bacterial infections. In the present work, we have designed some methyl 2-((4- acetylthiazol-2-yl)sulfanyl)-1,2,3,4-tetrahydro-6-methylpyrimidine-5-carboxylate as potential DHFR inhibitors through rational drug design approach.

Keywords

DHFR, Biginelli reaction, Pyrimidines, Antibacterial, Molecular docking

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