Hypertension is incredibly common in adults. High blood pressure is a leading cause of cardiovascular disease and death, even though it is not a disease in and of itself. Niosomes are considered superior among these carriers. Niosomes are structurally comparable to liposomes and exhibit equivalent efficacy in drug delivery. However, their greater chemical stability and cost-effectiveness make them a more advantageous choice over liposomes. Both niosomes and liposomes are composed of a bilayer structure, with niosomes consisting of a non-ionic surfactant and liposomes consisting of phospholipids. The niosomes were optimized by a factor of 32, and each formulation was divided by a factor of 22 to make hydrogels containing 1% w/v and 1.5% w/v chitosan. For example, if formulation F1 is used, it will be divided into two parts: F1Z1 and F2Z2, containing 1% w/v and 1.5% w/v chitosan, respectively. The optimized formulation, F1Z2, has a particle size of 342.9mm. The transmission electron microscopy (TEM) pictures of the optimized formulation revealed the presence of niosome vesicles in the formed sample. When the surfactant and cholesterol were taken in the same ratio, a higher percentage of encapsulation efficiency (%EE) was observed. However, increasing the amount of surfactant resulted in a drop in EE. The optimized formulation achieved a maximum entrapment efficiency of 89.4%. An 8-hour in-vitro release study was conducted, and the results indicate the maximum release. The drug release experiments for the produced formulations were conducted over a duration of 8 hours, and the highest observed release was 81.157%. The improved formulation F1Z2 had a Zeta potential value of -22.4 mV, indicating the system's stability. The stability study is conducted in accordance with the ICH recommendations. Three optimal formulations were chosen based on their entrapment efficiency. The parameters were meticulously upheld for the stability analysis. The stability investigation of all the formulations yielded positive results, indicating their stability.

Metoprolol succinate, Chitosan, Cholesterol, Antihypertensive Therapy, Niosomes.