Objective: The majority of the time, invasive endoscopic biopsies are employed as the current gold standard for diagnosing and tracking chronic gastritis. However, there is an increasing awareness of the need for patient-friendly, non-invasive diagnostic methods that are also economically viable. Along with playing a crucial protective function in the digestive system, saliva is also showing promise as a non-invasive diagnostic tool. This study intends to discover and characterize particular biochemical indicators in the saliva of patients with chronic gastritis, including both Helicobacter pylori-positive (HP+) and Helicobacter pylori-negative (HP-) persons, and compare these results with those of healthy individuals. With the eventual objective of using these indicators as a diagnostic tool, the research will also look into the association between the levels of these biochemical markers in both serum and saliva. Methods: The cross-sectional study design was used in this research investigation, which was carried out at the Mayo Hospital in Lahore. The objective was to evaluate the disease activity in 60 patients with chronic gastritis (44 with Helicobacter pylori positive and 16 with Helicobacter pylori-negative) using subjective symptoms, serological data, and endoscopic results. The patients' ages varied from 12.08 to 58.73 on average. The individuals in the control group, who were healthy and did not smoke, were on average 56.86 8.67 years old. Examining serum and saliva samples that had not been stimulated was part of the study. Additionally, several components including albumin, total protein, uric acid, and secretory immunoglobulin A (sIg A) were examined in stool samples. Using an ELISA reader designed for oral fluid processes and a biochemical analyzer (Olympus AU 640), the effectiveness of the tests was assessed. Results: When compared to the control group, the patients who got HP+ therapy had substantially greater levels of sIgA (secretory immunoglobulin A) and TP (total protein). The levels of UA (uric acid) didn't follow a similar trend, however. Our results revealed that only UA had a link with both saliva and blood levels. Intriguingly, endoscopic investigations showed an inverse correlation between UA levels and the presence of inflammation. These alterations are thought to represent a defense mechanism against oxidative stress, irregularities in salivary flow, and inflammation that developed in the stomach. Conclusions: Salivary characteristics are significantly altered in those with chronic gastritis brought on by Helicobacter pylori (HP+) infection. Even though saliva has significant limits, it may be a useful tool for detecting pathological alterations in the digestive tract, especially when an HP+ infection is present.

saliva, uric acid, gastric albumin