Background. Environmental conditions are a major contributor to pubertal maturation indicators in child population, particularly in girls. Object: identifying pubertal maturation characteristics of girls living in different cities of the republic. Materials and methods. A total of 1284 girls aged between 7 and 17 years living in territory of Tashkent city, the Republic of Karakalpakstan and 4 regional cities of the Uzbekistan (Samarkand, Syrdarya, Kashkadarya and Khiva) were studied. The initial, middle and final periodsof secondary pubertal patterns development as well as menstrual function were determined. Results and discussion. Girls in Karakalpakstan are on average 8-14 months behind their peers in regional cities and Tashkent in the main characteristics of pubic and axillary hair development, while they are 2-16 months ahead in mammary gland development. Compared to girls in Tashkent and other provincial cities of the republic, girls in Karakalpakstan have a longer period of puberty. Conclusion. Delayed puberty in girls is caused by adverse environmental factors in Karakalpakstan.

girls, pubertal maturation, secondary pubertal characteristics, environmental factors, Karakalpakstan