Volume 20 No 22 (2022)
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CLINICAL PROFILE, LABORATORY PARAMETERS AND SEVERITY PREDICTORS IN PATIENTS WITH FEVER AND THROMBOCYTOPENIA- EXPERIENCE OF A TERTIARY CARE CENTRE
Pandey , Pant KC, Kumar P, Maurya RK
Abstract
Fever with thrombocytopenia is a distinct clinical entity that refers to a reduction in platelet count
<1,50,000/µL. This is due to decreased production, increased destruction (immunogenic and nonimmunogenic) and increased sequestration in the spleen. There were 100 patients presenting with
fever with thrombocytopenia taken up for study. Out of these 100 cases, 59 cases were male and
41 were female with a male-female ratio is 1.44:1. The patients’ age ranged from 18 years to 67
years with a mean age of 33.3.8±14.19 years. Out of the 100 thrombocytopenic patients, only 29
(29 %) were symptomatic and suffered from bleeding manifestations, whereas the majority of the
patients (71%) had no bleeding manifestation. Fever with thrombocytopenia consists of the occult
presentation of a common disease rather than a rare disease. Febrile thrombocytopenia, a
commonly observed problem is most frequently caused by infections: viral diseases (dengue,
chikungunya, and other viruses), malaria, enteric fever etc. Febrile illness patients should be
investigated irrespective of the bleeding manifestations. Bleeding occurs usually but not always
with more severe thrombocytopenia. Late presentation to the hospital, prolonged fever, and signs
of end organ damage influence outcomes in these patients
Keywords
Thrombocytopenia, Fever, Viral diseases, Febrile thrombocytopenia
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