Aim: To examine the clinical characteristics of peripheral arterial disease (PAD) in individuals with chronic kidney disease (CKD). Materials and Methods: A cross-sectional observational study was conducted in the Department of Medicine at Sree Mookambika Institute of Medical Sciences, Kulasekaram, Southern India. The study included fifty patients admitted to the medical wards with a diagnosis of CKD. Results: The study identified that older age, prolonged duration of CKD, presence of coronary artery disease, comorbid diabetes mellitus, anemia, elevated parathyroid hormone (PTH) levels, increased high-sensitivity C-reactive protein (hsCRP), reduced estimated glomerular filtration rate (eGFR), elevated total cholesterol, high low-density lipoprotein (LDL) cholesterol levels, and presence of albuminuria were significantly associated with the development of PAD in patients with CKD. Conclusion: PAD is highly prevalent among patients with CKD in India. Significant risk factors include older age, diabetes mellitus, coronary artery disease, advanced stages of CKD, albuminuria, and elevated hsCRP levels. Early detection of patients with occult PAD may enhance preventive strategies and therapeutic outcomes. Keywords: Chronic kidney disease; Peripheral arterial disease

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