BACKGROUND: Thrombocytopenia is a potentially fatal illness and one of the most prevalent hematological disorders. The easiest way to differentiate between the two forms of thrombocytopenia—hyper-destructive and hypo productive—is by doing a bone marrow examination, but this is an invasive, time-consuming, and costly procedure. This study's objective was to ascertain if platelet indices have a role in differentiating between the two kinds using a non-invasive, cost-effective method of examination. METHODS:It was cross-sectional research carried out at the Mayo Hospital, Lahore between July 1, 2021, and June 30, 2022. The approach utilized was non-probability convenience sampling. A total of 74 thrombocytopenic patients who were sent for a bone marrow aspirate and a trephine biopsy were included in the research after the sample size was established using the WHO criteria. We collected and calculated data for the patient's medical record, complete blood count (CBC), and bone marrow trephine biopsy. RESULTS:In the hyper-productive group, the average platelet volume was 10.571.33 fl, whereas, in the hyper-destructive group, it was 11.6371.98 fl. There was a statistically significant difference between the groups (p=0.017). In the hypo-productive group, the platelet distribution width was 12.683.16 fl, but in the hyper-destructive group, it was 14.8113.61 fl (p=0.014). In the hypo-productive group, the platelet large cell ratio was 30.819.23%, but in the hyper-destructive group, it was 36.99310.25% (p=0.010). CONCLUSIONS:An effective method for differentiating between hyper-destructive and hypo-productive thrombocytopenia is platelet indices.

Platelet, Thrombocytopenia, Platelet Indices