Coloprotective role of vardenafil against the development of ulcerative colitis in rats through inhibition of NLRP3 signaling pathway

Volume 20 No 7 (2022)

Esraa Yehia, Elsayed M Kamel, Amal E Salem, Doaa M Abdullah

DOI: 10.14704/nq.2022.20.7.NQ33332

Abstract

Aims:Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disorder that known to increase the risk of colon cancer. Erectile dysfunction(ED) is common in patients with UC. Vardenafil, which is a drug commonly prescribed for treatment of ED, has been shown to have antioxidant effects; nevertheless, its significance in UC has not been determined. Thus, this current study was designed to investigate the potential prophylactic effects of vardenafil against acetic acid-induced UC and to identify possible underlying mechanisms

Keywords

ulcerative colitis, erectile dysfunction, vardenafil, Nrf2/Ho-1, NLRP3 inflammasome

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